Joint helps the body regrow the cartilage rather than just help the pain. The pain will naturally decrease as the cartilage stops deteriorating and begins to regenerate. It is wise to do some research on proper diets for Arthritis to aid your healing process.
Excerpts from the Harvard Medical School article Published in the prestigious journal Science
September 24, 1993
“Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis”
ABSTRACT: (actual text, emphasis added) “Rheumatoid arthritis is an inflammatory synovial disease thought to involve T cells reacting to an antigen within the joint. Type II collagen is a major protein in articular cartilage and is a potential autoantigen in this disease. Oral tolerization to autoantigens suppresses animal models of T cell-mediated autoimmune disease, including two models of rheumatoid arthritis. In this randomized, double-blind trial involving 60 patients with severe active rheumatoid arthritis, a decrease in the number of swollen joints and tender joints occurred in subjects fed chicken type II collagen for 3 months but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident. These data demonstrate clinical efficacy of an oral tolerization approach for rheumatoid arthritis.”
SELECTED QUOTE MATERIAL FROM THE ARTICLE TEXT:
Although the pathogenetic mechanisms underlying the disease are unknown, rheumatoid arthritis is associated with human lymphocyte antigen (HLA)-DR4 and considered to be an autoimmune [self-attacking-self] disorder in which activated T cells participate.
- Current treatments are inadequate in that they only partially control established rheumatoid arthritis. They also have side effects that limit use early in the disease process and interfere with prolonged administration.
- Experimental findings [from two animal studies] provided the rationale for a pilot [Phase One trial], open-label dose-escalation and safety study in 10 [human] patients with recalcitrant rheumatoid arthritis. Subjects were taken off their immunosuppressive and disease-modifying drugs consisting of methotrexate, 6-mercaptopurine, azathioprine, or auranofin and fed 0.1 mg of solubilized type II collagen daily for 1 month and then switched to 0.5 mg for the next 2 months …
- Six of the 10 patients experienced a substantial clinical response, defined by a greater than 50% improvement in both swollen and tender joint counts with two additional disease measures improving by greater than 50% in morning stiffness, 15-m walk time, grip strength. These improvements lasted for at least 2 months after the treatment period. Complete disease remission lasting for 26 months occurred in one of the ten subjects; included discontinuation of nonsteroidal anti-inflammatory drugs (NSAID).
- Based on the results of this Phase One study, a double-blind, placebo-controlled, Phase Two trial with 60 patients was undertaken to determine whether clinical efficacy could be demonstrated.
- Among the collagen patients, the decline in the number of swollen joints, tender joints, and joint-swelling and tenderness indices were all significant in comparison to the placebo patients.
- Four of the collagen patients (14%), as compared with none in the placebo group, had complete resolution of disease. At the beginning of the study these patients had had severe, active rheumatoid arthritis.
- While collagen patients were off immunosuppressive drugs, stability or improvement occurred, whereas patients in the placebo group tended to deteriorate.
- This controlled trial provides evidence that oral administration of type II collagen is both safe and can improve the daily physical challenges of rheumatoid arthritis.
Oral type II collagen is a preferable treatment because it appears to improve the health of the arthritic joint as evidenced by the joint functionality for several months after intake was canceled.
Oral type II collagen is not toxic like drugs and helps other parts of body as well as the joints.
Chicken Protein halts swelling, pain of arthritis patients in trial
WASHINGTON – A protein from chicken bones stopped the pain and swelling of rheumatoid arthritis for patients in a clinical experiment, and experts say the novel treatment holds promise for control of the crippling disease.
Dr. David Trentham, of Beth Israel hospital and Harvard Medical School in Boston, said that a collagen solution made from chicken cartilage and swirled into patients’ morning orange juice appeared to arrest the progress of rheumatoid arthritis in a small group that was studied.
The technique, which he called “oral tolerization”, seems to “teach” the body to stop inflaming the tissue around joints. Rheumatoid arthritis is thought to be an autoimmune disease caused by rogue cells of the immune system attacking membranes in joints.
Trentham said that swallowing protein that is similar to the membrane of the joints “reinstructs the body to cease the attack on the body’s own joints”.
All 28 patients taking the collagen during the three-month trial got relief from their disease and four went into remission, said Trentham. The disease became worse in 31 patients who received a placebo..
A report on the study is to be published today in the journal Svience.
Dr. Arthur Grayzel, senior vice president for medical affairs of the Arthritis Foundation, said he was quite encouraged by the study and believes oral tolerization techniques have the potential of halting rheumatoid arthritis. But he cautioned that a much larger trial of the collagen treatment should be undertaken.
The study used 60 rheumatoid arthritis patients selected from a group who had not responded well to conventional treatment.
A group of 28 were given daily solutions of what is called type II collagen derived from chickens.
“It is purified from chicken simply because that is the least expensive way of making it, and we can be sure it is free of viral contaminants,” said Trentham.
After three months, it was clear that the drug was beneficial.
Note: Although the reporter called Chicken Collagen Type II a drug it is really a component of chicken sternal cartilage and is considered an all natural product safe for human consumption with no side effects.
Barnett ML; Combitchi D; Trentham DE
Beth Israel hospital, Boston, MA 02215, USA.
Arthritis Rheum, 39(4):623-8 1996 Apr
OBJECTIVE: To evaluate the efficacy of oral chicken type II collagen (CCII) in the treatment of juvenile rheumatoid arthritis (JRA). METHODS: Ten patients with active JRA were treated with CCII for 12 weeks. Efficacy parameters, which included swollen and tender joint count and score, grip strength, 50-foot walking time, duration of morning stiffness, and patient and physician global scores of disease severity, were assessed monthly. RESULTS: All patients completed the full course of therapy. Eight patients had reductions in both swollen and tender joint counts after 3 months of CCII. The mean changes from baseline in swollen and tender joint counts for the 8 responders at the end of the study were -61% and -54%, respectively. Mean values for other efficacy parameters also showed improvement from baseline. There were no adverse events that were considered to be treatment related. CONCLUSION: Oral CCII may be a safe and effective therapy for JRA, and its use in this disease warrants further investigation.
Serving Size 4 Tablets (See Suggested Use)
Servings Per Container: Contains 30
Amount Per 4 Tablets Potency %Daily Value
Vitamin C (as magnesium ascorbate) 200 mg 334%
Magnesium (as magnesium oxide, ascorbate) 400 mg 100%
Copper (as copper glycinate)** 1 mg 50%
Manganese (as manganese glycinate)** 10 mg 500%
Molybdenum (glycinate)** 220 mcg 294%
Sodium (as glucosamine sulfate) 120 mg 6%
Glucosamine Sulfate 1,500 mg *
MSM LIGNISULTM (source of organic sulfur) 1,500 mg *
FLEXICOLTM Proprietary Blend 501.5 mg *
Containing: Premium Chicken Collagen Type II
naturally occurring Chondroitin Sulfate and Boron (as boron proteinate)
* Daily Value Not Established ** Albion Labs true mineral chelate
Other Ingredients: Cellulose, stearic acid, Magnesium Stearate, Crosscarmellose Sodium, Silicon Dioxide, and Hydroxypropylmethylcellulose.
As a dietary supplement take two (2) tablets twice daily with
meals, or as directed by a health care professional.
For best results use a minimum of 8 to 12 weeks.